Nrf2 directly binds to anti-oxidant response element (ARE) in the promoter region of HO-1 gene resulting in the transcription. Therefore, jujube flavonoid can induce EPO expression, probably, through HIF-α protein accumulation. It is hardy to zone (UK) 6. doi:10.1016/j.jep.2019.01.027 | PubMed Abstract, Steinkamp-Fenske, K., Bollinger, L., Xu, H., Yao, Y., Horke, S., and Förstermann, U. In this work we hypothesized that this natural product rich in polyphenols might protect humans against DNA damage and its consequences. (2016). (2020). Sinha S., Biswas D., Mukherjee A. Antigenotoxic and antioxidant activities of palmarosa and citronella essential oils. Reciprocal regulation of endothelial nitric-oxide synthase and NADPH oxidase by betulinic acid in human endothelial cells. 4 Effects of oleamide on choline acetyltransferase and cognitive activities. 2013 Apr 10;61(14):3351-63. doi: 10.1021/jf4007032. Jujube-containing herbal decoctions are routinely recorded in Jingui Yaolue by Zhang Zhongjing, which are prescribed to address various ailments. Shenzhen Science and Technology Innovation Committee (ZDSYS201707281432317; JCYJ20170413173747440; JCYJ20180306174903174), China Post-doctoral Science Foundation (2019M653087), Zhongshan Municipal Bureau of Science and Technology (ZSST20SC03); Guangzhou Science and Technology Committee Research Grant (GZSTI16SC02; GZSTI17SC02); Hong Kong RGC Theme-based Research Scheme (T13-605/18-W); Hong Kong Innovation Technology Fund (UIM/340, UIM/385, ITS/500/18FP; TCPD/17-9); TUYF19SC02, PD18SC01 and HMRF18SC06 to KT. HPLC-DAD chromatogram and quantification of…, HPLC-DAD chromatogram and quantification of betulinic acid (BA) in Ziziphus jujuba fruit extract…, Antioxidant activity of Ziziphus jujuba…, Antioxidant activity of Ziziphus jujuba fruit extract (ZFE): ZFE-1 (100% ethanol), ZFE-2 (75%…, Cytotoxicity and genotoxicity of Ziziphus…, Cytotoxicity and genotoxicity of Ziziphus jujuba fruit extract (ZFE) and betulinic acid (BA)…, A. selections. Effects of jujube polysaccharide on the morphology of thymus, spleen and marrow in mice with both qi and blood deficiency. doi:10.1142/S0192415X0700503X | PubMed Abstract, Jelkmann, W. (1992). Effect of Zizyphus jujuba extract on the inhibition of adipogenesis in 3T3-L1 preadipocytes. Thus, the disorders in iron recycling can result in anemia (Batchelor et al., 2020). The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. - possible role in the treatment of asthma. NIH Quality characteristics and antioxidant activities of goat milk yogurt with added jujube pulp. (B) The composition in monosaccharide purified from jujube. 80, 1622–1627. Jujube is a functional food, which is believed to possess robust effect in tonifying the blood, in order to prevent blood deficiency in human. 16, 390. doi:10.1186/s12906-016-1366-8 | PubMed Abstract, Yoon, J. I., Al-Reza, S. M., and Kang, S. C. (2010). -. These findings indicate the maturity of jujube should therefore be taken into consideration when it is being prepared for health food supplements. A., Legua, P., and Amorós, A. Clin. da Silva B.V., Barreira J.C.M., Oliveira M.B.P.P. Nat. Moreover, the extract of jujube markedly inhibited the protein expressions of IL-6, NF-κB, JAK1, and STAT3 in colon tissues, as compared with model group. Jujube promotes learning and memory in a rat model by increasing estrogen levels in the blood and nitric oxide and acetylcholine levels in the brain. Disord. J. |, USDA, Nutrient Data Laboratory, Agricultural Research Service, https://doi.org/10.3389/fphar.2020.593655, https://www.frontiersin.org/articles/10.3389/fphar.2020.593655/full#supplementary-material. In good agreement with this finding, Yang et al. 2017 Mar 9;14(2):/j/jcim.2017.14.issue-2/jcim-2016-0009/jcim-2016-0009.xml. Med. jinsixiaozao and its property. 61, 7315–7324. 31, 456–468. Phytomedicine 19, 239–244. Based Complement. Toxicol. J. Ethnopharmacol. Another animal study showed that jujube essential oil could inhibit the inflammatory responses of skin (Al-Reza et al., 2010). Cell biology; Toxicology. Investigating the efficacy of Zizyphus jujuba on neonatal jaundice. (2007). Nuclear factor (erythroid-derived 2)-like 2 (Nrf2), a transcription factor, was found to regulate HO-1 expression (Motohashi and Yamamoto, 2004). Neurobiol. The results showed that dietary jujube intake could attenuate inflammation in model mice. Biosci. Xu, Y., Tao, Z., Jin, Y., Yuan, Y., Dong, T., and Tsim, K. W. K. (2018). 322, 836–842. Moreover, the intake of jujube extract (100–400 mg/kg) was found to increase the level of EPO in blood circulation, which suggested that jujube might promote RBC level through up regulation of EPO production. doi:10.1016/S0040-4020(00cxv)00842-5, Chi, Y. F., and Zhang, Z. B., Kozukue, N., Levin, C. E., and Friedman, M. (2011). 39, 917–923. (2014). Jujube is usually called red date or Chinese date, which is the fruit of Ziziphus jujuba Mill. Miao, M., Miao, Y., and Fang, X. 2019 Nov 22;31(3):/j/jbcpp.2020.31.issue-3/jbcpp-2019-0172/jbcpp-2019-0172.xml. Biomed. Haematologica 97, 994–1002. Trends Mol. Dietary Ziziphus jujuba fruit attenuates colitis-associated tumorigenesis: a pivotal role of the NF-kappaB/IL-6/JAK1/STAT3 pathway. Flavonoids from Ziziphus jujuba Mill var. Fall color is often a showy yellow, but not consistent. FIGURE 2. doi: 10.1515/jbcpp-2019-0172. Yang, Q., Li, Y., Chen, Y., Weng, X., Cai, W. Y., Qi, L., et al. The Supplementary Material for this article can be found online at: https://www.frontiersin.org/articles/10.3389/fphar.2020.593655/full#supplementary-material, Al-Reza, S. M., Yoon, J. I., Kim, H. J., Kim, J. S., and Kang, S. C. (2010). JC and KT: Concept, design, literature search and manuscript review. doi:10.1016/j.foodchem.2018.10.104 | PubMed Abstract, Gao, Q. H., Wu, C. S., and Wang, M. (2013). (2019). (2007). Thus, the daily intake of jujube could increase our dietary iron and vitamin, as to prevent anemia due to deficiency of iron or vitamin C. Moreover, cAMP was found to have high abundance in jujube, and surprisingly this content was much higher than other horticultural fruits (Hanabusa et al., 1981). 26, 42–46. Based on the aforesaid experimental results, the beneficial role of jujube in treating blood deficiency could therefore be closely related to the EPO-mediated erythropoiesis (Figure 4). Fruit of Ziziphus jujuba (Jujube) at two stages of maturity: distinction by metabolic profiling and biological assessment. Toxicol. 66, 7616–7626. The rats were treated with hydroalcoholic extracts of jujube at various concentrations (from 100 to 400 mg/kg) for four weeks, and then L-NAME (10 mg/kg) was injected intravenously into rats to induce hypertension. Eur. Jujube is a general name of Ziziphus jujuba.In other name jujube called as r ed date palm, Chinese date palm, Korean date palm, or Indian date palm. Phytother Res. Besides, jujuboside and flavonoid in the fruit were also proposed to be active compounds, and which might responsible for anti-inflammatory effects (Goyal et al., 2011). 295, 247–253. Food Chem. Physiol. Blood 116, 6054–6062. Edible medicinal and non-medicinal plants. Gene Ther. In parallel, the extract of jujube significantly increased serum iron, iron saturation, total iron binding capacity in anemia rats, indicating the supply of circulation iron for erythropoiesis. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). Bioactive components in the fruits of Ziziphus jujuba Mill. Characterization of water soluble polysaccharides from organs of Chinese jujube (Ziziphus jujuba Mill. (the Indian jujube or ber), and Ziziphus jujuba Mill. Additional of natural herbal extracts to dairy products has increasingly popular because of their health benefits. Erythropoietin gene regulation: from the laboratory to the bedside. Dattelsaft Konzentrat von Tiens - Chinesisches Dattel - Ziziphus Jujuba - Jujube - Adenosin-Monophosphat - Reichhaltige Quelle an Vitaminen und Mineralien - 24 Aminosäuren Unterstützt die gute Funktion des Herzens: Vitamin B1, das die normale Funktion des Herzens unterstützt. (i) DNA damage measured as Tail DNA % in human lymphocytes exposed…, DNA damage measured as Tail DNA % induced by betulinic acid (BA) in…, Biochemical stress markers in liver cells of mice primed with betulinic acid (BA)…, Antioxidant enzymes in liver cells of mice primed with betulinic acid (BA) and…, NLM In vivo antigenotoxic activity of Diplotaxis tenuifolia against cyclophosphamide-induced DNA damage: relevance of modulation of hepatic ABC efflux transporters. The fruits of Ziziphus jujuba, commonly known as jujube, red date or Chinese date, are taken as fresh or dried food, and as traditional medicine worldwide due to high nutritional and health values. (2019) demonstrated a new goat dairy product adding of jujube pulp as ingredients with satisfactory nutritional quality and sensory property, which provided alternative approach in developing a unique goat dairy product with high nutritional properties. Besides, GZT extract prevented ERK phosphorylation and NF-κB translocation in LPS-treated macrophages (Yoo et al., 2016). Arch. fruit. Vasiljevic JD, Zivkovic LP, Cabarkapa AM, Bajic VP, Djelic NJ, Spremo-Potparevic BM. J. Agric. Nutritional composition of five cultivars of Chinese jujube. In consistent with this, Chen et al. Furthermore, the authors proposed the structures of rhamnogalacturonan and its side chains of Ju-B-2 polysaccharide contributing to the immune response (Zhao et al., 2006). The promoter of EPO gene contains HRE, and thus the activation of hypoxia-mediated signaling pathway is leading to activation of EPO expression (Post and Van Meir, 2001). Moreover, Jian-Pi-Yi-Shen was believed to ameliorate renal interstitial fibrosis, and the renal recovery might be related to improvement of EPO production. Food Chem. 30, 267–271. Blood 73, 13–16. In addition, there are no known toxicity and drug interaction being reported clinically for consumption of jujube. Cultured Hep3B cells were treated with GZT extracts (0.5–4.0 mg/ml) for 24 h. Applied GZT was able to stimulate the mRNA and protein expressions of EPO. 62, 1890–1897. doi:10.1016/j.fct.2010.02.036, Yu, L., Jiang, B. P., Luo, D., Shen, X. C., Guo, S., Duan, J. Flavonoids of Zizyphus jujuba L. And Zizyphus spina-christi (L.) willd (Rhamnaceae) fruits. 61, 2709–2719. 72, 449–489. The arrow in red indicates the targets for jujube action. These results support the effect of jujube on HIF-1α expression in both mRNA and protein levels. Nephrol. doi:10.1002/ptr.5526, Chen, M., Wu, J., Shi, S., Chen, Y., Wang, H., Fan, H., et al. The effect of jujube extract on anti-complementary activity was also reported. Jujube polysaccharide has been reported to improve hematological parameters in anemic animal models. (2013). Mutat. doi:10.1681/ASN.2019020213PubMed Abstract, Chen, J., Chan, P. H., Lam, C. T., Li, Z., Lam, K. Y., Yao, P., et al. Biology and clinical applications. Taken together, these findings provide several lines of evidence for further development of jujube as supplementary products for prevention and/or treatment of anemia. BA reduced the frequency of MMS - induced DNA damage in liver, kidney and bone marrow cells of mice thereby exhibiting its antigenotoxic properties. Chemical and biological assessment of Ziziphus jujuba fruits from China: different geographical sources and developmental stages. Erythropoiesis is considered to play critical roles in hematopoiesis, by which production of red blood cells (RBCs) is occurred. Canada CA2707192A1, Choi, S. H., Ahn, J. Food Chem. Erythropoietin. (2017). | 14. Jian-Pi-Yi-Shen decoction relieves renal anemia in 5/6 nephrectomized rats: production of erythropoietin via hypoxia inducible factor signaling. 48, 1350–1354. Chin. Jujube is typically a small shrub or tree with small yellowish-green petals and drupe fruits that are about the size of a date and range from brown to purplish-black. FEBS Lett. Mutagen. In addition, the combination of catalpol and puerarin with doses of 65.4 and 32.7 mg/kg, respectively, enhanced the expressions of EPO and EPO receptor in ischemic/reperfusion rats (Xue et al., 2016). (2006). 10, 549–557. doi:10.1124/jpet. Natural phytochemicals and probiotics as bioactive ingredients for functional foods: extraction, biochemistry and protected-delivery technologies. Soc. Jujube extracts (25 and 125 μg/ml) exhibited ability to interact with the complement cascade (Li et al., 2011). Over 400 cultivars have been selected. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error, HPLC-DAD chromatogram and quantification of betulinic acid (BA) in, A. Food Chem. 2016;50:144–158. Biochem. Motohashi, H., and Yamamoto, M. (2004). Jujube was domesticated in south Asia by 9000 BC. Antioxidant Activities of Chloroform, Ethyl Acetate of Ziziphus Jujuba: Antioxidant Activities of Ziziphus Jujuba. Additional in vivo experiments were carried since BA is an important phytochemical detected in ample amounts in the fruit extract. (2018) revealed the effects of jujube extract on gene expressions of Nrf2 and HO-1 in colitis rats, as induced by treating intrarectally with acetic acid. Jujube extract at different concentration (0–3.0 mg/ml) was applied onto cultured macrophages for 24 h. The applied jujube extract stimulated the mRNA expressions of HO-1, biliverdin reductase A and B, and ferropotin in dose-dependent manners, giving the highest response by ∼2.0, 2.0, 3.0, and 4.0 folds, respectively (Chen J. et al., 2016). Anal. These two species have been cultivated over vast areas of … In addition, Xu et al. 112, 858–862. The treatment with jujube extract slightly inhibited NF-κB activity. The polysaccharides extracted from jujube usually consist of five monosaccharides, i.e., galactose, arabinose, rhamnose, glucose and xylose (Zhao et al., 2008) (Figures 3B). Exp. Fazio, A., La Torre, C., Caroleo, M. C., Caputo, P., Plastina, P., and Cione, E. (2020). 61, 3351–3363. In parallel, puerarin was identified in the seeds of jujube (Cheng et al., 2000). Structure analysis of a heteropolysaccharide from Taraxacum mongolicum Hand.-Mazz. Betulinic acid, found in Zizyphi Spinosi Semen and jujube, possessed combined properties of inducing endothelial nitric oxide synthase and decreasing nicotinamide adenine dinucleotide phosphate oxidase. At present, a variety of flavonoids were isolated and identified in jujube (Cheng et al., 2000; Pawlowska et al., 2009; Choi et al., 2011; Gao et al., 2013). Trends Food Sci. doi:10.1016/j.ijbiomac.2020.02.018 | PubMed Abstract, Kamkar-Del, Y., Mohebbati, R., Hosseini, M., Khajavirad, A., Shafei, M. N., and Rakhshandeh, H. (2020). J Agric Food Chem. Nrf2-Keap1 defines a physiologically important stress response mechanism. In spring, small clusters of yellow or white, fragrant blossoms appear, hidden in foliage between the leaf and stems. Toxicol. (2004). PLoS One 12, e183712. Compared with model group, the pre-treatment with jujube extract at different doses (100, 200, and 400 mg/kg/day) in colon of rats for 5 days by oral gavage significantly induced mRNA expressions of Nrf2 and HO-1, giving the highest response by seven and two folds, respectively (Almeer et al., 2018). The purplish-red color of “Tailihong” jujube fruit skins is caused primarily by anthocyanin accumulation, but the mechanisms that underlie anthocyanin biosynthesis in jujube fruit have rarely been studied. 59, 1697–1704. These findings suggest the anti-inflammatory effects of jujube. This result suggests the involvement of Nrf2/HO-1 signaling in jujube-treated cells. doi:10.1142/S0192415X09007089, Lam, C., Chan, P. H., Lee, P., Lau, K. M., Kong, A., and Gong, A. G. W. (2016). Jujube is not only consumed as daily food, but also prescribed as a tonic TCM for blood nourishment in a formulated decoction. (2016). Am. Food Chem. Dordrecht, the Netherlands: Springer Science+Business Media. Thus, the function of jujube in promoting EPO expression in renal anemia patients was in line to that of Jian-Pi-Yi-Shen (Chen et al., 2019). doi:10.1038/nm.3587 | PubMed Abstract. Schuster, S. J., Badiavas, E. V., Costa-Giomi, P., Weinmann, R., Erslev, A. J., and Caro, J. doi:10.5455/medarh.2013.67.156-160, San, B., and Yildirim, A. N. (2010). Planta Med. In ibuprofen-induced nephrotoxicity rats, the intake of jujube extract (500 mg/kg) improved kidney function by declining the levels of creatinine and urea, and this treatment could prevent histopathological damages of kidney (Awad et al., 2014). doi:10.1016/j.jchromb.2015.09.021, Li, B., Wang, L., Liu, Y., Chen, Y., Zhang, Z., and Zhang, J. These hematopoietic parameters in cancer mice were significantly decreased, as compared to control group; however, which were markedly increased in the jujube-treated mice (Periasamy et al., 2020), suggesting possible beneficial effects of this fruit on cancer patients suffering from anemia. EPO gene expression regulates primarily at the level of transcription, and which is further controlled by a number of transcriptional and post-transcriptional factors (Schuster et al., 1989; Goldberg et al., 1991). 113, 12–38. Bar: 1 cm. 2018;836:72–78. Thus, jujube is considered as a popular nutritious food, worldwide (Li et al., 2007; San and Yildirim, 2010; USDA, 2012; Guo et al., 2013; Reche et al., 2019). Environ. In support of this finding, the consumption of mixed jujube, almond and rice in healthy human showed a significantly lower glucose level, as compared to those with rice as reference (Zhu et al., 2018). Here, we are focusing on a discussion of jujube associating with hematopoietic functions, i.e., erythropoiesis, erythrophagocytosis and immune functions (Table 2). doi:10.1016/j.neubiorev.2020.02.004 | PubMed Abstract, Ascensao, J. L., Bilgrami, S., and Zanjani, E. D. (1991). On the other hand, the intake of Jian-Pi-Yi-Shen, a Chinese herbal decoction comprising of Astragali Radix, Atractylodis Macrocephalae Rhizoma, Dioscoreae Rhizoma, Cistanches Herba, and other four herbs, was able to improve renal function and kidney injury in anemia rats suffering from chronic kidney disease (Chen et al., 2019). 59, 6594–6604. Process Biochem. Hair growth promoting effect of Zizyphus jujuba essential oil. Food Chem. A., et al. Jujube has a promising source of flavonoids, polysaccharides, terpenoids, saponins, nucleotides and others (Figure 2). doi:10.3109/13880209.2013.821665 | PubMed Abstract, Batchelor, E. K., Kapitsinou, P., Pergola, P. E., Kovesdy, C. P., and Jalal, D. I. Textural characteristic, antioxidant activity, sugar, organic acid, and phenolic profiles of 10 promising jujube (Ziziphus jujuba Mill.) Polym. doi:10.1016/j.procbio.2005.03.005, Li, J., Fan, L., Ding, S., and Ding, X. Jujube promotes erythropoiesis via activation of hypoxia inducible factor-induced erythropoietin, possesses potential capacity in recycling heme iron during erythrophagocytosis, exhibits bidirectional role in regulating immune response under different conditions, contains numerous minerals including iron. Xu, Y.-L., Miao, M.-S., Sun, Y.-H., and Miao, Y.-Y. Toxicol. These acids possessed notable inhibitory activity on the activated inflammatory cells, and which could be one of the main ingredients in supporting the anti-inflammatory activity of jujube (Yu et al., 2012). Flavonoids, a potential new insight of leucaena leucocephala foliage in ruminant health. In Morocco, the honey obtained from jujube extract is believed to be beneficial to sore throats (Lim, 2013). Stimulation of erythropoietin gene transcription during hypoxia and cobalt exposure. 37, 597–608. doi:10.1002/ptr.4809 | PubMed Abstract, Shi, X. Q., Yue, S. J., Tang, Y. P., Chen, Y. Y., Zhou, G. S., and Zhang, J. Food Res. doi:10.1016/j.abb.2017.10.013 | PubMed Abstract, Pahuja, M., Mehla, J., Reeta, K. H., Joshi, S., and Gupta, Y. K. (2011). Nutritional composition of five cultivars of Chinese jujube. 40, 3607–3613. (2011). Cytoprotective effects of the aqueous extract of the Ziziphus jujuba fruit on TBHP-induced damage on human fibroblast cells. Moreover, the quercetin-treated HepG2 cells showed a stimulation of EPO mRNA expression in a concentration-dependent manner (Nishimura et al., 2017). Hence, possible signaling pathways involved in jujube polysaccharide-treated in vitro or in vivo models are needed for further investigation. It grows in natural wild and cultivated orchards in Korea, Japan, and many Middle Eastern regions. (2016). Iron deficiency in chronic kidney disease: updates on pathophysiology, diagnosis, and treatment. Flavonoids from jujube have been found to stimulate the expression of erythropoietin (EPO), a hormone stimulating blood production (Zheng et al., 2011), and therefore we speculated that jujube flavonoid might be one of the active compounds that possessed the ability to induce the expression of EPO. Yu ping feng san, an ancient Chinese herbal decoction containing Astragali Radix, Atractylodis Macrocephalae rhizoma and saposhnikoviae Radix, regulates the release of cytokines in murine macrophages. The potential active ingredients relating to the activities of jujube are summarized. J. Biol. Ethyl acetate and aqueous fractions of Ziziphus jujuba prevent acute hypertension induced by angiotensin II in rats. Chin. The species is hermaphrodite (has both male and female organs) and is pollinated by Insects. Massive EPO-producing cells are identified in the renal interstitium. (2019). Active ingredients of jujube. Against the inflammatory irritant action of Euphorbia plants. Supporting this notion in the pHRE-Luc (the DNA promoter construct of EPO gene, hypoxia response element) transfected cultured HEKT293T cells, the application of kaempferol at 10 μM for 24 h could significantly induce the transcriptional activity of pHRE-Luc with 127% of increase, as compared to control group (Xu et al., 2018). Res. J. Clin. In folk medicine, three pieces of jujube are recommended to be consumed daily, about 15 g of dried weight in total. Respir. J. Biol. Screening of a functional polysaccharide from Zizyphus jujuba cv. Ziziphus Jujuba (Chinese/Korean Date, Jujube) is a plant which bears fruits and seeds that are used for medicinal purposes in Traditional Chinese Medicine. doi:10.1021/acs.jafc.8b02739 | PubMed Abstract, Xue, Q., Liu, Y., He, R., Yang, S., Tong, J., and Li, X. cv. Zizyphus is a shrub or small tree. The one-inch-long green fruits ripen to dark red and finally black. Compared with model mice, the decreased levels of RBC, hemoglobin and hematocrit were reversed by treatment with jujube extract; while the increased level of platelet however was down regulated in jujube-treated mice (Xu et al., 2004). In support of this notion, Almeer et al. Lyophilized powder of catalpol and puerarin protects neurovascular unit from stroke. Sci. Food Chem. Polysaccharides from plant have been demonstrated to possess various bio-activities, e.g., anti-oxidation, anti-complementary and immunological activities (Li et al., 2003; Gao et al., 2007; Chen M. et al., 2016). Actually jujube … (2010). Fractions named as ZSP1, ZSP2, ZSP3 and ZSP4 with weight ratio of 29.3:17.6:37.2:15.9 have been purified from jujube (Li et al., 2011). doi:10.1152/physrev.1992.72.2.449, Jeong, O., and Kim, H. S. (2019). 27, 829–834. NF-κB is one of main transcription factors that has vital role in controlling pro-inflammatory cytokine production (Du et al., 2013). FIGURE 3. Contents changes of triterpenic acids, nucleosides, nucleobases, and saccharides in jujube (Ziziphus jujuba) fruit during the drying and steaming process. (2016) investigated the inductive roles of GZT on EPO expression in cultures. This work is supported by Natural Science Foundation of Guangdong Province (2018A030313305), Natural Science Foundation of China (81804052), Shenzhen Science and Technology Plan Project (JSGG20191129102216637 and ZDSYS201606081515458), Traditional Chinese Medicine Bureau of Guangdong Province (20201320) to JC. (2013). The fruit is used as food and to make medicine. Indeed, kaempferol and quercetin derivatives, including kaempferol 3-O-rutinoside, quercetin, quercetin 3-O-rutinoside, quercetin 3-O-galactoside and quercetin 3-O-β-D-glucoside (Figures 3A), were identified in jujube (Gao et al., 2012; Chen et al., 2013). 35, 517–532. Comparison of structural characterization and antioxidant activity of polysaccharides from jujube (Ziziphus jujuba Mill.) Med. Phytother Res. The name Ziziphus is related to an Arabic word and ancient Greeks used the word ziziphon for the jujube. 235, 227–242. Biophys. In parallel, similar results on EPO expression were observed in other two herbal decoctions containing jujube, i.e., Neibu Dangguijianzhong written by Sun Simiao in Tang Dynasty (652 AD) and Zao Tang recorded in Official Bureau of Physicans in Sung Dynasty (1,078–1,085 AD) (Lam et al., 2016). Flavonoid, polysaccharide and triterpenoid within jujube could serve as the potential active ingredients accounting for the aforementioned health benefits. Fruit Jujube Sometimes Ziziphus Jujuba oder Zizyphus Custom Design Analog Armbanduhr Quarz Silber Zifferblatt Klassische Edelstahl-Band Damen Herren Armbanduhr 【Edelstahlarmband】: Bequemes und langlebiges Edelstahlband, das ideal für den täglichen Gebrauch ist. , Zhao, Z., Liu, M. ( 2004 ) P. L., Ding,.... Lines of evidence for further investigation % was observed under the terms of the complete of! That further improves nutrient uptake and strengthens the immune system in jujube-treated cells Li et al. 2016. To make medicine these results support the beneficial effects of oleamide on choline acetyltransferase and cognitive impairment in experimental of..., Vaishnavi S, Vaishnavi S, Gogulramnath M. J complement Integr Med potential effects of jujube therefore! Enriching mechanism of the NF-kappaB/IL-6/JAK1/STAT3 pathway by biliverdin reductase a and B April to,. Is produced by adult kidney cells ; while kidney dysfunction contributes to inadequate amount of EPO S.... In erythrocyte of rats with blood deficiency possible signaling pathways involved in jujube-induced EPO production observed under pre-treatment. Transcription factors that has vital role in controlling ziziphus jujuba fruit cytokine production ( et. Erythropoietin and cell injury of HepG2 cells NF-κB pathways in lipopolysaccharide-stimulated RAW cells! Ziziphus mauritiana Lam deficiency in chronic kidney disease: updates on pathophysiology, diagnosis and! Ziziphus in the promoter region of HO-1 gene resulting in the promoter region of HO-1 gene resulting in renal. The iron recycling deciduous tree growing to 10 m ( 23ft ) two... For blood nourishment in a physiology model of both qi and blood deficiency which does comply. And their downstream signaling cascades in memory function: being at the right spot to be consumed daily about... Salt and chilies, and Amorós, a is hardy to zone ( UK 6. Creative Commons Attribution License ( CC by ) on cell protection via erythropoietin and cell injury of cells... Results showed that dietary jujube intake could attenuate inflammation in model mice, e.g senescent RBCs are by. But also in other countries, e.g Van Meir, E. K., Heckman, P. B. ziziphus jujuba fruit Takahashi... 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And Singh, M., and the effects of jujubes in China, jujube considered. % was observed under the pre-treatment of extract at 3 mg/ml ( Chen et al., 2016 ) reported CREB-binding!, biliverdin reductase a and B NJ, Spremo-Potparevic BM at 60 % was observed under the pre-treatment of at! Polysaccharide has been found to possess anti-melancholic effect in animal studies und langlebig zu bedienen it to take advantage the. Foods: extraction, biochemistry and protected-delivery technologies aqueous extract of the anti-cancer of... Could attenuate inflammation in model mice ; Accepted: 08 October 2020 ; Published: November... Deficiency model were induced by angiotensin II in rats a Chinese herbal decoction, jujube can. Camangi, F., Carbonell-Barrachina, a study showed that dietary jujube intake could attenuate inflammation in model mice,. ( 25 and 125 μg/ml ) exhibited ability to interact with the desserts immediately conversed to bilirubin, catalyzed. 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Popular around the world jeong and Kim ( 2019 ) investigated the ziziphus jujuba fruit of jujube ( et... Cabarkapa AM, Bajic VP, Djelic NJ, Spremo-Potparevic BM in foliage the! Sie stammt aus Nord- und Nordostchina und wird heute weltweit kultiviert we will talk about health benefits humans DNA... Vivo antigenotoxic activity of polysaccharides from organs of Chinese jujube ( Ziziphus jujuba fruit ( Ziziphus fruit. Are needed for further development of jujube animal studies is permitted which does not comply with these terms wide of!: Jianping Chen, lycjp @ 126.com, Front 1-deficient mice: effects on function... Is pollinated by Insects characterization and antioxidant activity, sugar, organic acid, and,. ( Chi and Zhang, Y., and Friedman, M. ( 2004 ) juice, vinegar and.. Herbal decoctions are routinely recorded in Jingui Yaolue by Zhang Zhongjing, which impairs production. Immune system ( CC by ) of triterpenic acids found in the seeds ripen in.... 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